{"id":5755,"date":"2021-04-02T12:17:44","date_gmt":"2021-04-02T12:17:44","guid":{"rendered":"https:\/\/techclot.com\/index.php\/2021\/04\/02\/ai-in-drug-discovery-starts-to-live-up-to-the-hype\/"},"modified":"2021-04-02T12:17:44","modified_gmt":"2021-04-02T12:17:44","slug":"ai-in-drug-discovery-starts-to-live-up-to-the-hype","status":"publish","type":"post","link":"https:\/\/techclot.com\/index.php\/2021\/04\/02\/ai-in-drug-discovery-starts-to-live-up-to-the-hype\/","title":{"rendered":"AI in Drug Discovery Starts to Live Up to the Hype"},"content":{"rendered":"

AI in Drug Discovery Starts to Live Up to the Hype<\/a><\/p>\n

The past few years have seen several flashy demonstrations of how artificial intelligence (AI) algorithms may transform biomedical research, particularly with respect to drug discovery. This past November, for example, Google\u2019s AI subsidiary, DeepMind, announced that its AlphaFold program could deliver computational predictions of protein structure that approach the quality of those provided by gold-standard experimental techniques such as X-ray crystallography.1<\/sup><\/p>\n

Such high-profile announcements have elicited justifiable excitement about the future of algorithmically guided drug development, but AI\u2019s champions in the industry remain wary about overselling the technology\u2019s current capabilities. \u201cI still feel that there\u2019s a lot of hype around it,\u201d says Paul Nioi, PhD, senior director of research at Alnylam Pharmaceuticals. \u201cCompanies are springing up that claim to solve all the issues of drug discovery, target discovery, and development using AI. I think that\u2019s yet to be proven.\u201d<\/p>\n

Nevertheless, a growing number of companies now recognize the value that AI\u2014and more specifically, the subset of algorithmic techniques known as \u201cmachine learning\u201d\u2014can deliver at various stages in the drug discovery process. \u201cThere\u2019s an increase in investment across all of the companies that I\u2019ve talked to,\u201d relates Peter Henstock, PhD, machine learning and AI lead at Pfizer.<\/p>\n

\u201cThe capabilities are still being sorted out,\u201d Henstock adds. \u201cIn most cases, we\u2019re still negotiating how to go about using it effectively.\u201d But the opportunities are clear, and machine learning\u2013based techniques are already finding a place in early-stage target discovery and drug development workflows\u2014and offering a glimpse of the gains in efficiency and success rates that the future could bring.<\/p>\n

A deep dive into the literature<\/strong><\/h4>\n

The vast majority of biomedical data are imprisoned in unstructured formats that are, in their raw form, inaccessible to computational analysis. Data are trapped within publications, patents, clinical records, and other documents that are exclusively targeted at human readers. Natural language processing (NLP) algorithms offer a powerful solution to this problem. These employ a machine learning technique known as deep learning to analyze documents and other datasets and identify biologically relevant text elements such as the names of genes, proteins, drugs, or clinical manifestations of disease.<\/p>\n

NLP algorithms can rapidly comb through vast collections of data and identify previously overlooked patterns and relationships that might be relevant to a disease\u2019s etiology and pathology. Henstock\u2019s team used such an approach to scrutinize PubMed\u2019s tens of millions of abstracts. \u201cJust by text mining,\u201d he points out, \u201cwe could basically take some genes and figure out what diseases might be related to them.\u201d<\/p>\n

The Pfizer group subsequently incorporated other dimensions into its analysis, looking at publication patterns to identify \u201ctrending\u201d areas of disease research where rapid scientific progress might offer a solid foundation for rapidly shepherding a drug development program into the clinic. According to Henstock, this approach achieved a greater than 70% success rate in identifying patterns of heightened disease research activity that ultimately gave rise to clinical trials.<\/p>\n

The value of NLP-mined data can be greatly amplified by threading together structured data from multiple sources into a densely interconnected \u201cknowledge graph.\u201d \u201cWe have huge amounts of data in different areas, like omics\u2014chemical-related, drug-related, and disease-related data,\u201d says Natnael Hamda, an AI specialist at Astellas Pharma. \u201cIngesting that data and integrating those complex networks of biological or chemical information into one collection is tricky.\u201d<\/p>\n

The rewards, however, can be considerable, as the resulting interconnections tell a much richer biological story than any one dataset on its own. For example, these interconnections can enable more sophisticated predictions of how to develop therapeutic agents that safely and effectively target a particular medical condition.<\/p>\n

AI-focused startup Healx relies heavily on knowledge graphs assembled from a diverse range of public and proprietary sources to gain new insights into rare genetic diseases. The company\u2019s chief scientific officer, Neil Thompson, PhD, notes that this category encompasses roughly 7,000 diseases affecting on the order of 400 million patients in total\u2014but treatments are available for only 5% of these disorders.<\/p>\n

\u201cOur main focus is on finding new uses for old drugs,\u201d says Thompson, \u201cWe are working with all the data on the 4,000 FDA-registered drugs, and we are building data on drugs registered elsewhere in the world.\u201d This information is complemented by data provided by the various patient organizations with which Healx collaborates.<\/p>\n

According to Thompson, this approach has yielded an excellent success rate, with multiple disease programs yielding candidates that demonstrated efficacy in animal models. One of these programs, a treatment for the intellectual developmental disorder fragile X syndrome, is on track to enter clinical trials later this year.<\/p>\n

Getting a clearer picture<\/strong><\/h4>\n

Machine learning is also effective for extracting interesting and informative features from image data. Alnylam has been using computer vision algorithms to profile vast repositories of magnetic resonance imaging (MRI) data collected from various parts of the body in tens of thousands of patients with various medical conditions. \u201cWe\u2019re training a model based on people that we know have a certain disease or don\u2019t have a certain disease,\u201d says Nioi, \u201cand we\u2019re asking the model to differentiate those two categories based on features it can pick up.\u201d<\/p>\n

One of the lead indications for this approach is nonalcoholic steatohepatitis (NASH), a hard-to-treat condition in which fat accumulation in the liver contributes to inflammation and scarring\u2014and ultimately, cirrhosis. NASH is a chronic condition that gradually worsens over time, and MRI analysis could reveal early indicators of onset and progression as well as biomarkers that demonstrate the extent to which a therapy is preventing the disease from worsening.<\/p>\n

\u201cThe idea is to put the disease on a spectrum, so that you can look for these different points of intervention,\u201d explains Nioi. He notes that this approach has already led to some promising drug targets, and that his company is now looking to apply a similar approach to neurological disease.<\/p>\n

Several other companies are using machine learning\u2013based image analysis to go deeper into their analyses of disease pathology. For example, cancer immunotherapies can vary widely in their efficacy because of differences in the structure and cellular composition of the \u201cmicroenvironment\u201d within a tumor, including the strength of the local immune response.<\/p>\n

\u201cWe can now apply computer vision to identify the spatial condition of the tumor microenvironment,\u201d asserts Hamda. \u201cWe are getting huge amounts of omics data at the cellular level, and we can characterize the microenvironment of a tumor cell by applying deep neural networks.\u201d This kind of approach is proving valuable in analyses of the extensive (and publicly available) datasets that are being generated by the Human Cell Atlas Project, The Cancer Genome Atlas Project, and other initiatives.<\/p>\n

Progress has been slower in terms of applying AI for the actual design of drugs themselves, but machine learning continues to be explored as a means of improving the performance of existing drug candidates. \u201cSmall-molecule drugs are a multivariate optimization problem, and humans are not very good at doing that,\u201d observes Henstock. His team is working with self-training algorithms that can tweak such compounds based on a variety of physicochemical criteria, and he believes a similar approach should also be suitable for antibody drugs\u2014a class of proteins for which the structural and biochemical features are particularly well defined.<\/p>\n

Alnylam is also using machine learning to fine-tune its therapeutics, which are based on chemically modified RNA sequences that directly interfere with the expression of disease-related genes. \u201cWe\u2019re thinking about designing molecules that optimally knock down a target\u2014[and] only the target that you\u2019re interested in\u2014without broad effects on the transcriptome,\u201d says Nioi.<\/p>\n

AI on the rise<\/strong><\/h4>\n

After 20 years at Pfizer, Henstock is seeing unprecedented enthusiasm around making AI a core part of the company\u2019s processes. \u201cI ran an AI course three years ago \u2026 that seemed to change a lot of the conversations,\u201d he recalls. \u201cWe had executive meetings that actually put themselves on hold so they could attend this session.\u201d<\/p>\n

\"Artificial
According to MarketsandMarkets, AI in drug discovery represents a market that will attain a global value of $1.4 billion by 2024, up from $259 million in 2019, reflecting a compound annual growth rate of 40.8%. This growth is driven by factors such as the growing number of cross-industry collaborations and partnerships, the increasing need to develop drugs more quickly and cost effectively, the rising adoption of cloud-based computing, and the impending patent expiry of blockbuster drugs. [metamorworks\/Getty Images]<\/figcaption><\/figure>\n

A similar transition is playing out elsewhere. At Astellas, for example, investments in AI are extensive. \u201cThere are so many big AI or machine learning initiatives here,\u201d says Hamda, who began working with Astellas as a research fellow in 2020.<\/p>\n

It takes skilled experts who know their way around the dense forest of available algorithms to make the most of these capabilities. Hamda notes that choosing the wrong computational approach for a given research question can be disastrous in terms of wasted time and resources.<\/p>\n

\u201cI fear that some companies are developing \u2018black box\u2019 software,\u201d he continues. \u201c[It\u2019s possible that] people are just entering input and collecting output without knowing what\u2019s going on inside.\u201d He emphasizes the importance of planning and building explainable and reproducible computational workflows that allow the users to trust the quality of the resulting models.<\/p>\n

Although many machine learning techniques are generalizable across fields, effective implementation in the context of drug discovery also requires deep expertise in the relevant scientific disciplines. Henstock recalls starting at Pfizer as an engineer with a doctorate in AI.<\/p>\n

\u201cI couldn\u2019t understand the chemists or the biologists\u2014they speak their own language and have their own concepts,\u201d he says. \u201cAnd if you can\u2019t understand what they\u2019re trying to get at, you can\u2019t really do your job very well.\u201d This disconnect motivated him to return to school for a biology degree.<\/p>\n

Building out such capacity is costly and labor intensive, and some companies are opting for a hybrid model in which some AI-oriented projects are contracted out to smaller startups for which computational biology is the primary focus. For example, Alnylam has partnered with a company called Paradigm4 for key aspects of its machine learning\u2013guided drug development efforts. \u201cIt\u2019s really down to resources,\u201d declares Nioi. \u201cThere are people that do this for a living and spend their entire time focused on one problem, whereas we\u2019re juggling many things at the same time.\u201d<\/p>\n

But in the long run, the gains from bringing AI on board could be huge. In a 2020 article, Henstock cited projections indicating that the pharmaceutical industry could boost earnings by more than 45% by making strong investments in AI.2<\/sup> \u201cThis means making some interesting tradeoffs in how we do science, how we approach problems, and how we approach our processes,\u201d he explains. \u201cBut it\u2019s kind of critical because you can do better experiments with greater richness.\u201d<\/p>\n

References<\/em>
1. <\/em>Callaway E. \u2018It will change everything\u2019: DeepMind\u2019s AI makes gigantic leap in solving protein structures. Nature 2020; 588: 203\u2013204.<\/em>
2. Henstock P. Artificial Intelligence in Pharma: Positive Trends but More Investment Needed to Drive a Transformation. Arch. Pharmacol. Ther. 2020; 2(2): 24\u201328.<\/em><\/p>\n<\/p>\n

Published at Fri, 02 Apr 2021 11:01:10 +0000<\/p>\n

Build a Post-Pandemic AI Strategy for Resilience, Recovery<\/a><\/p>\n

<\/header>\n

As companies recover from the pandemic, scaling AI capabilities across the organization can bring the agility and speed demanded to stay competitive.<\/span><\/p>\n

\n\"Image:<\/a><\/p>\n

Image: iaremenko – stock.adobe.com<\/span><\/p>\n<\/div>\n

Expectations are high for artificial intelligence\u2019s ability to prime businesses for post-pandemic resiliency, and rightfully so. Research firm IDC predicts<\/a> that global spending on AI will double over the next four years, growing to more than $110 billion in 2024. Research from Accenture also shows that companies that successfully scale AI achieve nearly 3x the return on investment<\/a> and a 30% premium on key financial valuation metrics.  <\/p>\n

While the hype around this technology is not new, the COVID-19 pandemic sharpened the contrast between those who have professionalized their AI capabilities to scale across the enterprise, and those who have yet to tap into the full value of their AI investments. In an attempt to recover and achieve sustainable growth beyond 2021, it will be crucial for companies to embrace evolving AI capabilities by transforming into an intelligent enterprise that embeds analytics into the core of its operations.<\/p>\n

Stages of AI maturity <\/strong><\/p>\n

As we enter a new era of technololgy, work and life, there will be increasing pressures for IT leaders to quickly scale AI and its techniques — including machine learning, natural language processing, knowledge representation, computational intelligence, and more — to enable an automated, intelligent and insight-driven organization. Our research shows that most C-suite executives (84%) believe they must leverage AI to achieve their growth objectives, but most do not know where to start, with 76% of execs reporting that they struggle with how to scale.<\/p>\n

If you\u2019re still in the early stages of AI maturity, you\u2019re not alone. In our experience, most companies (80-85%) are still in the initial proof of concept phases, resulting in a low scaling success rate, and ultimately a lower ROI. Often IT-led, these small-scale efforts tend to be siloed within a department or team and lack a connection to a business outcome or strategic imperative.<\/p>\n

In parallel, we\u2019ve seen that very few organizations (<5%) have progressed to the most advanced point of AI sophistication. These companies have a digital platform mindset and create a culture of AI with data and analytics democratized across the organization. Businesses that are industrialized for growth are consistently scaling models with a responsible AI framework to promote product and service innovation. Our research shows that strategic, wide-scale AI deployment will enable competitive differentiation, correlated with significantly higher financial results.<\/p>\n

Putting principles to practice  <\/strong><\/p>\n

To scale effectively — no matter where your company currently stands in its AI journey —  IT leaders and their teams must professionalize their AI approach, categorizing AI as a trade with a shared set of principles and guidance. Here are four strategies to keep top of mind as you advance your organization\u2019s digital capabilities: <\/p>\n

    \n
  1. Establish sustainable multidisciplinary teams<\/strong> of diverse perspectives, skills and approaches that work together to innovate and deliver AI products or services that can be cross-functional. When doing this it is also important to clarify core roles and primary skills for team members and business  product owners to ensure teams have clarity in what they are expected to bring to the table.<\/li>\n
  2. Define ways of working<\/strong> that enable multidisciplinary teams to work together effectively, deliver the best products and services, and innovate predictably and efficiently. For example, Accenture\u2019s Legal organization teamed with our Global IT Applied Intelligence group to develop a solution to the challenge of managing and sorting through the thousands of legal documents that are transacted each month. The Applied Intelligence team worked side-by-side with the Legal team to apply predictive models, artificial intelligence, and machine learning to create a robust and self-learning search tools that helps our Legal team easily perform precise information searching and extraction, unleashing data that was previously not easily accessible. User interface and experience skills were just as important to ensure our end-users were able to easily exploit the power of the AI models.<\/li>\n
  3. Demand education<\/strong> and training to create confidence in AI technology, with clear qualifications and standards for practitioners. Implementing regular assessment points throughout employees\u2019 careers can be a useful benchmark to test their knowledge and maintain their technical education. Equipping all employees with the understanding and examples of where AI technologies are most effective helps to direct scarce resources towards areas with the highest chance of initial success. If needed, partnerships with research and academic institutions can be a useful strategy to reskill employees and strengthen future talent pipelines.<\/li>\n
  4. Democratize AI<\/strong> literacy to empower your entire<\/em> workforce to have access to specialist teams or technology they can leverage in this quickly advancing space. Making AI intelligence accessible to everyone at your organization will help your company as a whole achieve stronger and faster returns on investment. It will encourage new ideas and better collaboration across the business.<\/li>\n<\/ol>\n

    A big challenge for any technology is scaling across the enterprise, and AI is no exception. To push an idea through to a real solution with tangible benefits often requires rethinking the role of the technology completely. By formalizing your AI strategy, IT leaders will be poised to help their organization achieve more value from AI, create a more agile and connected workplace, and gain a competitive advantage in the race to scale.<\/p>\n

    \n<\/a>\n<\/div>\n

    Mark Dineen is a part of the Applied Intelligence team for Accenture\u2019s global IT organization, leading the company\u2019s internal AI studio and delivery capabilities. These global teams have responsibility for creating and delivering new data-driven insights to all of Accenture using design thinking, advanced analytics and machine learning. <\/em><\/p>\n

    The InformationWeek community brings together IT practitioners and industry experts with IT advice, education, and opinions. We strive to highlight technology executives and subject matter experts and use their knowledge and experiences to help our audience of IT … View Full Bio<\/a><\/span><\/p>\n

    We welcome your comments on this topic on our social media channels, or [contact us directly]<\/a> with questions about the site.<\/div>\n

    More Insights<\/span><\/p>\n<\/p>\n

    Published at Fri, 02 Apr 2021 10:52:30 +0000<\/p>\n","protected":false},"excerpt":{"rendered":"

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